water soluble vitamins

Water-soluble vitamins.

water soluble vitamins

The water-soluble Vitamins include vitamin C and all other vitamins designated B. The letter are collectively referred to as the vitamin B complex. The water-soluble vitamins bear less resemblance to each other than do the fat-soluble vitamins. Whereas the fat-soluble vitamins are isoprenoid structures and largely of hydrocarbon composition, the water-soluble vitamins all possess polar groupings to render them water-soluble.

A. Vitamin C,

Now called ascorbic acid, is the vitamin that prevents scurvy. A person with scurvy suffers pain in the joints and hemorrhages from the mucous membranes of the mouth. The gums especially are affected and become red, ulcerated, and even gangrenous. Ascorbic acid is abundantly found in citrus fruits, tomatoes, green peppers, and parsley. It should be obtained from fresh sources for it loses its potency when heated or when exposed to air for any length of time. Ascorbic acid is a hexose derivative with the following structure.

Ascorbic Acid

B. The B Vitamin Complex.

Vitamin designated as B vitamins were at one time all thought to be the same. The isolation of each new factor from vitamin B preparations has led to a designation of B1, B2, B3, etc, for each new factor. B vitamins appear to play an important role in energy metabolism. A brief discussion of the principle B vitamin is given in the following section.

Vitamin B1 (Thiamine).

A deficiency of which causes beriberi in humans is present in whole cereal grains, legumes, lean meat, nuts, and yeast. The vitamin has been found to contain both the pyrimidine and thiazole heterocyclic system. The structure of thiamine has been determined, and the vitamin has been prepared. Thiamine usually is prepared in the form of an acid salt.

Thiamine occurs in nature either as the pyrophosphoric acid ester or as the free vitamin.

Vitamin B2 (Riboflavin).

Is an orange-yellow, crystalline compound widely distributed in nature. It is found in milk, lean meats, liver, fish, eggs, and leafy vegetables. A lack of riboflavin in the diet causes inflammation of the lips, dermatitis and dryness and burning of the eyes, accompanied by a sensitivity to light. The structure of riboflavin is shown.


Vitamin B3 Niacin (Nicotinic acid), 

Another of the B vitamins is the antipellagra factor. Pellagra is a disease characterized by dermatitis, a pigmentation, and thickening of the skin, and soreness and inflammation of the tongue and mouth.

Niacin may be found in most of the same foods that supply riboflavin. Especially rich sources of niacin are lean meats and liver. Although present in whole cereal grains, niacin is lost in the milling process. The niacin structure is part of the enzyme nicotinamide-adenine-dinucleotide  (NAD). The structural formula of niacin, shown below, is relatively simple when compared to those of other vitamins. The oxidation of nicotine or b-picoline (3-methylpyridine) produces nicotinic acid or niacin.

Vitamin B6 (Pyridoxine).

Is a vitamin whose function appears to be intimately related to the proper metabolism of fats and amino acids. Meat, fish, egg yolk, and whole cereal grains are rich sources of vitamin B6. The exact requirements of vitamin B6 for adult humans has not been established, but a lack of pyridoxine of vitamin B6 for adult humans has not been established, but a lack of pyridoxine in the diet of experimental animals leads to dermatitis, anemia, and epileptic seizures. The structures of pyridoxine and two of its derivatives which also show vitamin B6 activity are given below.

Vitamin B12.

Is the vitamin that prevents pernicious anemia. It is a dark red crystalline compound with a complex structure. Like heme and chlorophyll-a, it also contains a porphyrin nucleus, but a unique feature of its structure is the presence of trivalent cobalt. Vitamin B12 was the first cobalt-containing organic compounds to be found. It sometimes is referred to as cobalamin. It is found most abundantly in liver but also occurs in meat, eggs, and seafoods. The structure of vitamin B12 is shown in Fig. 1.1.

Vitamin B12

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