Nitrofurantoin Side Effects.
“Nitrofurantoin side effects” Adverse effects upon administration of Nitrofurantoin’s are :
- very common, such as diarrhea because Indiscriminate antibiotic kills bacteria in the gut;
- it is possible to obtain allergic attack; have particular difficulty in breathing;
- increasing the content of glucose in the urine; liver problems upon chronic use;
- preparing a pain in the knees, legs;
Sometimes you may observe the following symptoms: headache, vaginal dryness, watery stools or blood;
‘Nitrofurantoin Mono‘ The chemical name of nitrofurantoin macrocrystals is 1-[[[5-nitro-2- furanyl]methylene] amino]-2,4-imidazolidinedione.
Melting point: 270 to 272 °C
Molecular Weight: 238.16
Nitrofurantoin and alcohol.
Alcohol in combination with nitrofurantoin leads to adverse toxic effects on the body. Active substance accumulates in blood plasma.
‘Nitrofurantoin Uses’ Nitrofurantoin active ingredient constitutes drugs with antibacterial nature. Bacteria in which an effect are two types of gram-negative and gram-positive. In pharmacies is only available on prescription. Not recommended the use of the drug during pregnancy, lactation and is not suitable for small children. Nitrofurantoin has a bactericidal effect against staphylococci, streptococci, enterococci, E. coli, Enterobacteriaceae aerogenes, Proteus mirabilis, Shigella, Salmonella, Clostridium perfringens
The drug is metabolized h Ernie liver by cytochrome enzymes. after metabolism in the body is eliminated by rens.
The pharmaceutical market has nitrofurantoin 25 mg, 50 mg and 100 mg capsule a suspension and a powder.
Although symptomatic bacteriuria does not usually require antibiotic therapy, the latter is recommended in pregnant patients, patients infected with Proteus species, patients with severe diabetes.
“Nitrofurantoin dosages” of the drug are tailored according to the age of the patient, as well as to infection, which is manifested: In acute cystitis adult: 50 to 100 mg four times a day;
After repetition of cystitis: 100 mg four times daily for 7 days.
For prophylaxis one tablet of 50 or 100 mg is sufficient for one day.
For young children, a pediatric physician dose is 1 to 2 mg/kg per day.
For children over 12 years, the dose is 100 mg twice daily only during the present iteration of urinary infection.
When poisoning with medication is only possible to perform hemodialysis.
increased absorption with food or agents delaying gastric emptying.
Diagnosis and treatment. of uncomplicated acute cystitis are relatively easy, while the complicated and recurrent infections require specialized research and treatment. In the treatment of urinary tract infection or a first uncommon infection, 3-daily antibiotic courses are better than the unit dose and typically equally effective for the 7-day with fewer side effects and better compliance failures. Unit dose rates have a greater incidence of treatment failure. In undiagnosed complicating factor (diabetes, pregnancy, anatomical abnormalities) this frequency is even higher.
Anticholinergic agents may increase the absorption (absorbance) and the oral bioavailability of nitrofurantoin (nitrofurantoin). The proposed mechanism involves extending the transit time of nitrofurantoin in the gastrointestinal tract due to a reduction of locomotor activity (peristalsis) of the stomach and intestines from anticholinergics. Biperiden (biperiden) alkaloids of Atropa belladonna, atropine, scopolamine, homatropine, hyoscyamine.
For concomitant or subsequent use without observing the recommended washout period of leflunomide (leflunomide), other drugs that may lead to liver toxicity, including NSAIDs (non-steroidal anti-inflammatory) and salicylates may potentiate the liver damage associated with the use of leflunomide. There have been reports of elevated liver transaminases, hepatitis, jaundice, cholestasis, hepatic failure and acute hepatic necrosis in the use of leflunomide. Elevations in liver enzymes are generally moderate (2-fold above normal) and clear with continued therapy. other medications associated with liver damage, including methotrexate (methotrexate), TNF-alpha blockers (TNF-alfa blockers), hydroxychloroquine (hydroxychloroquine), paracetamol (acetaminophen), non-steroidal anti-inflammatory drugs and statins risk of hepatotoxicity.
The research was done on the use of vitamins of group B, as well as Vitamin C and Vitamin D3 cholecalciferol no adverse effects were observed in combination with nitrofurantoin.
Decreased absorption with magnesium trisilicate.
Decreased renal excretion of Nitrofurantoin by probenecid and sulfinpyrazone.
Decreased anti-bacterial activity by carbonic anhydrase inhibitors and urine alkalinization.
Anti-bacterial antagonism by quinolone anti-infectives.
Interference with some tests for glucose in urine.
Author. Nidelina Petkova